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The Francis Crick Institute is an extraordinary example of collaborative work in science today. A consortium of six of the UK's largest organisations for biomedical research, the Institute brings together multidisciplinary groups of researchers to develop ground-breaking research for the improvement of human health. To house this centre, we devised a building that operates both as a complex laboratory as well as a place for collaboration and exchange. Working together with HOK, we have designed the building to be highly interactive and open, with five floors of laboratories above ground specifically designed to promote interdisciplinary work.